Hemostatic adaptations following a high-intensity interval training intervention in healthy men

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dc.contributor.advisor Nagelkirk, Paul R.
dc.contributor.author Sackett, James Randalll
dc.date.accessioned 2015-05-15T12:15:03Z
dc.date.available 2015-05-15T12:15:03Z
dc.date.issued 2015-05-02
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/123456789/199577
dc.description en_US
dc.description.abstract High intensity interval training (HIIT) is a novel mode of exercise training that has been shown to improve several components of health in various healthy and diseased populations. Purpose: The purpose of the present study was to examine hemostatic adaptations in healthy adult men following four and eight weeks of a HIIT intervention. Methods: Twenty-­‐one healthy but sedentary men (age: 25 ± 5 yrs; BMI: 26.7 ± 6.2 kg/m2) volunteered to participate in the present study. Subjects completed eight weeks of HIIT that included three to six ‘all out’ Wingate tests three days/week. Overall blood coagulation was assessed at baseline, following four weeks, and following eight weeks by clotting times of activated partial thromboplastin time (APPT) and prothrombin time (PT), and plasma concentration of fibrinogen. Plasma was obtained from whole blood samples taken at rest. A repeated measures ANOVA was used to compare the overall coagulation potential. Significance was set to p < 0.05. Results: There were no significant differences between resting heart rate, resting blood pressure, APTT (baseline: 43.0 ± 5.4; 4w: 42.7 ± 5.1; 8w: 44.2 ± 6.2), and PT (baseline: 13.0 ± 0.9; 4w: 12.9 ± 0.6; 8w: 13.1 ± 0.8), after 4w or 8w of HIIT. Fibrinogen concentrations significantly decreased from baseline to 4w (p < 0.05) and significantly increased from 4w to 8w (p < 0.05). Conclusion: Although beneficial fibrinogen changes were seen following four weeks of training, these findings were reversed after eight weeks. These observations suggest that HIIT may elicit improvements in coagulation potential after four weeks, but continued training may lead to elevated coagulation and/or inflammation via fibrinogen, which is recognized as a key regulator of inflammation and disease. en_US
dc.description.sponsorship School of Physical Education, Sport, and Exercise Science
dc.subject.lcsh Fibrinogen.
dc.subject.lcsh Interval training -- Physiological aspects.
dc.subject.lcsh Thrombosis -- Prevention.
dc.title Hemostatic adaptations following a high-intensity interval training intervention in healthy men en_US
dc.description.degree Thesis (M.S.) en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1787150


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  • Master's Theses [5256]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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