Identification of allele specific function of Candida ablicans Pseudouridine Synthase 4

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dc.contributor.advisor Bernstein, Douglas
dc.contributor.author Embree, Caleb
dc.date.accessioned 2019-04-05T16:17:41Z
dc.date.available 2019-04-05T16:17:41Z
dc.date.issued 2018-05
dc.identifier.other A-389
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/123456789/201542
dc.description.abstract Candida albicans is the most prevalent human fungal pathogen. Unfortunately, there still remains much that is unknown about it, including the reason for maintaining a diploid genome and the function of many genes. In this thesis I describe the phenotypic consequences of up and downregulating Pseudouridine Synthase 4 (PUS4) of C. albicans, as well as an examination of the differences in the expression level of the entire transcriptome. These experiments and resulting bioinformatic analysis have lead to our conclusion that that PUS4A is more lowly transcribed than PUS4B. This data suggests PUS4A may be nonfunctional or play a different role in C. albicans biology. en_US
dc.description.sponsorship Honors College
dc.subject.lcsh Biology.
dc.title Identification of allele specific function of Candida ablicans Pseudouridine Synthase 4 en_US
dc.type Undergraduate senior honors thesis.
dc.description.degree Thesis (B.?) en_US


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  • Undergraduate Honors Theses [5596]
    Honors theses submitted to the Honors College by Ball State University undergraduate students in partial fulfillment of degree requirements.

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