Akt and ERK activation in human skeletal muscle : dose-dependency of responses to increasing muscle contractions

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dc.contributor.advisor Trappe, Scott William en_US
dc.contributor.author Mazzetti, Scott A. en_US
dc.date.accessioned 2011-06-03T19:28:41Z
dc.date.available 2011-06-03T19:28:41Z
dc.date.created 2003 en_US
dc.date.issued 2003
dc.identifier LD2489.Z68 2003 .M39 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/178162
dc.description.abstract Akt activation mediates increases in glycogen synthesis in response to insulin in humans, while extracellular signal-regulated kinase (ERK) activation increases gene transcription and protein translation in response to endurance and resistance exercise. Akt activation increases only in response to intense muscle contractions and during hypertrophy in rats. No study has examined Akt and ERK activation with increasing numbers of intense muscle contractions in humans. Therefore, the primary objectives of this investigation were to determine if Akt activation increases in response to resistance exercise in humans, and to compare the changes in Akt and ERK activation in response to increasing numbers of muscle contractions.Akt and ERK activation were compared in muscle biopsy samples from 7 men before (Pre) and after (Post) knee extension and control protocols using enzyme linkedimmunosorbent assays. Baseline information was obtained including body composition and maximal strength (1-RM). Subjects were familiarized with knee extensions performed at 70% of 1-RM and a specified repetition cadence (2sec up, 2sec down). Once/wk, subjects performed one protocol in random order: 1 repetition (rep), 10reps, 3 sets of l0reps (3x10), or 6min of sitting. Akt activation decreased 42%, while ERK activation increased 108% in response to 3x10 (p<0.05). Akt and ERK activation did not change with 1 and 10reps, and thus their responses were not dose-dependent with resistance exercise in humans. The findings from this study represent the first indication that Akt activation is reduced in response to resistance exercise in human skeletal muscle, possibly to help mediate reductions in glycogen synthesis. en_US
dc.description.sponsorship Human Performance Laboratory
dc.format.extent xiii, 80 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Protein kinases -- Physiological effect. en_US
dc.title Akt and ERK activation in human skeletal muscle : dose-dependency of responses to increasing muscle contractions en_US
dc.title.alternative Protein kinase B and extracellular-signal related kinase activation in human skeletal muscle en_US
dc.title.alternative Title from approval sheet: Effects of different resistance exercise protocols on Akt and ERK activation in human skeletal muscle en_US
dc.description.degree Thesis (Ph.D.) en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1259313 en_US


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  • Doctoral Dissertations [3090]
    Doctoral dissertations submitted to the Graduate School by Ball State University doctoral candidates in partial fulfillment of degree requirements.

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