The effect of dietary fatty acids on cholesterol/phospholipid ratios and fatty acids in plasma membranes of spontaneous mammary tumors from strain A/ST mice

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dc.contributor.advisor Bennett, Alice S. en_US
dc.contributor.author Gridley, Shelly M. en_US
dc.date.accessioned 2011-06-03T19:35:03Z
dc.date.available 2011-06-03T19:35:03Z
dc.date.created 1989 en_US
dc.date.issued 1989
dc.identifier LD2489.Z78 1989 .G75 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/183785
dc.description.abstract It has been suggested that plasma membranes play a role in tumor production. Changes in plasma membrane lipid composition may change membrane fluidity and disrupt cellular communication. These changes in membrane lipid composition appear to be related to the fatty acid content of the animal's diet. The purpose of this investigation was to compare the effect of dietary linoleic and stearic acids and tumor size on cholesterol/phospholipid ratios and fatty acids in membranes of mammary adenocarcinomas.Plasma membranes of mammary tumors from Strain A/St mice were isolated by centrifugation and the lipids extracted. Phospholipid content was assayed by the method of Bartlett (102); cholesterol and fatty acids by gas liquid chromatography.Plasma membranes of tumors from mice fed the high linoleic diet (SAFF) were found to have the highest cholesterol/phospholipid ratios (Mean=0.396); mice fed high stearic acid diets produced tumors with the lowest ratios (0.280). Membranes of tumors from mice fed SA-4 and Stock diets had intermediate ratios (0.0.341 and 0.0.346, respectively).
dc.description.sponsorship Department of Biology
dc.format.extent v, 50 leaves ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Tumors -- Nutritional aspects. en_US
dc.subject.lcsh Cell membranes -- Abnormalities. en_US
dc.subject.lcsh Fatty acids. en_US
dc.subject.lcsh Cholesterol. en_US
dc.subject.lcsh Phospholipids. en_US
dc.subject.lcsh Breast -- Cancer. en_US
dc.title The effect of dietary fatty acids on cholesterol/phospholipid ratios and fatty acids in plasma membranes of spontaneous mammary tumors from strain A/ST mice en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/722452 en_US


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  • Master's Theses [5318]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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