The parameters of Cyclosporine A induced inhibition of a T cell dependent antibody response

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dc.contributor.advisor Behforouz, Nancy en_US Schilke, Angela J. en_US 2011-06-03T19:35:26Z 2011-06-03T19:35:26Z 1990 en_US 1990
dc.identifier LD2489.Z78 1990 .S3 en_US
dc.description.abstract Cyclosporine A (CsA) is a widely used immunosuppressive drug which has novel, clinically beneficial effects on the immune system. Substantial evidence indicates that CsA acts preferentially by impairing T cell lymphokine production, but there is some evidence that CsA may also affect B cells and other antigen presenting cells directly. Using an in vitro antibody response to sheep red blood cells, we have examined the effect CsA has on different populations of mouse lymphocytes. CsA appears to have a direct inhibitory effect on highly purified B cells from naive animals in a dose dependent manner at physiologically achievable levels in vitro. Even antigen stimulated B cells were found to be sensitive to the late addition of CsA when the drug was added simultaneously with lymphokine. B cells and T cells briefly pulsed with CsA do not recover to produce antibody when CsA is removed. Indeed, B cells from naive animals treated in vivo with CsA and stimulated in vitro with lymphokine and SRBC to produce antibody are profoundly inhibited from producing PFC despite the absence of CsA in culture. These findings suggest that CsA has direct irreversible, fast acting inhibitory effects on B lymphocytes aside from or in addition to its effects on T cells.
dc.description.sponsorship Department of Biology
dc.format.extent viii, 41 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Cyclosporine. en_US
dc.subject.lcsh Immunosuppressive agents. en_US
dc.title The parameters of Cyclosporine A induced inhibition of a T cell dependent antibody response en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5318]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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