The investigation of the zinc transport mechanism by model liposomes

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dc.contributor.advisor Pattison, Scott, 1947- en_US Friar, Steven D. en_US 2011-06-03T19:36:15Z 2011-06-03T19:36:15Z 1993 en_US 1993
dc.identifier LD2489.Z78 1993 .F75 en_US
dc.description.abstract An ionic gradient source and a complimentary transport system regulates the flow of ions across a cell membrane. The major objective of the research focused on analyzing kinetic data to better understand the zinc transport mechanism. This study examined passive diffusion as a possible mode for zinc transport by using a liposome model system. There is a connection between bilayer fluidity (packing order of fatty acids) and rates of diffusion and this was evaluated by choosing lipids that vary with chain length and the degree of saturation or unsaturation. Zinc diffusion kinetics were monitored by observing spectral differences in the visible region of the spectrum in order to determine optimal wavelengths for the calculation of rate constants. The final objective was to calculate a permeability coefficient for each type of liposome and to make comparisons to the permeability of zinc into hepatocytes which has a permeability coefficient of about 1 X 10-7 cm/s. All liposomes used were phosphatidylcholine based. The values of the permeability coefficients for the liposomes used in this project were comparable to permeability in hepatocytes which suggest the potential importance of passive diffusion as a means for transporting biological zinc.
dc.description.sponsorship Department of Chemistry
dc.format.extent 90 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Zinc -- Physiological transport. en_US
dc.subject.lcsh Zinc in the body. en_US
dc.subject.lcsh Liposomes. en_US
dc.subject.lcsh Cell membranes. en_US
dc.title The investigation of the zinc transport mechanism by model liposomes en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5318]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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