Effects of UV radiation on Marfan syndrome cells in culture

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dc.contributor.advisor Beattie, Ruth E. en_US
dc.contributor.author Allman, Amy J. en_US
dc.date.accessioned 2011-06-03T19:36:20Z
dc.date.available 2011-06-03T19:36:20Z
dc.date.created 1993 en_US
dc.date.issued 1993
dc.identifier LD2489.Z78 1993 .A46 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/184674
dc.description.abstract Ultraviolet radiation causes an alteration in DNA by modifying neighboring thymine bases resulting in the formation of a dimer. These dimers block the processes of transcription and translation and ultimately no protein is synthesized and the cell dies. However, DNA repair mechanisms correct this damage by excising the dimer from the DNA strand and inserting replacement bases which are joined to the original strand by DNA ligase. This allows transcription to resume and ultimately protein synthesis to take place.This research focused on determining the DNA damage and subsequent repair levels in a connective tissue disorder, namely Marfan syndrome. This information is important in understanding the clinical expression and management of life threatening conditions in Marfan syndrome individuals.Preliminary results indicate that at 20-25J/m2 UV dose (254nm) Marfan syndrome skin cells show a mean reduced survival value of 12% compared to normal human skin cells. Gel electrophoresis indicates a reduced DNA repair level 24h post UV irradiation for Marfan syndrome skin cells compared to normal human skin cells. These results suggest Marfan syndrome skin cells have reduced survival and DNA repair levels compared to normal human skin cells.
dc.description.sponsorship Department of Biology
dc.format.extent xi, 85 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Ultraviolet radiation -- Physiological effect. en_US
dc.subject.lcsh Marfan syndrome -- Genetic aspects. en_US
dc.subject.lcsh DNA -- Analysis. en_US
dc.title Effects of UV radiation on Marfan syndrome cells in culture en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/879841 en_US

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  • Master's Theses [5318]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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