Decreased Lactobacillus populations after erythromycin treatment hinders the induction of oral tolerance to fed ovalbumin

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dc.contributor.advisor Bruns, Heather A.
dc.contributor.author Lambert, Sydney E.
dc.date.accessioned 2012-05-22T19:21:33Z
dc.date.available 2013-12-26T20:17:46Z
dc.date.created 2012-05-05
dc.date.issued 2012-05-05
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/123456789/195902
dc.description.abstract Oral tolerance is an immunologic hyporesponsiveness to an orally administered antigen. Probiotics (beneficial intestinal bacteria), T regulatory cells (Tregs), and dendritic cells (DCs) are all essential for generating tolerance and suppressing immune responses toward harmless antigens. Antibiotics are commonly prescribed to fight infections and often necessary for maintaining health, but they can disrupt the normal intestinal microbial populations. There is increasing epidemiologic evidence that suggests that antibiotic usage correlates with the development of irritable bowel disorders, which often result due to a breakdown in immune tolerance. This study investigated the effect of the antibiotic erythromycin on oral tolerance induction to ovalbumin (OVA). The results demonstrate that antibiotic treatment prior to exposure to fed antigen prevents tolerance to that antigen, and this correlated with a reduction in intestinal Lactobacillus populations. Furthermore, antibiotic treatment resulted in a significant decrease in the tolerogenic CD11c+/CD11b+/CD8α- MLN DCs independent of tolerizing treatment.
dc.description.sponsorship Department of Biology
dc.subject.lcsh Lactobacillus
dc.subject.lcsh Erythromycin -- Physiological effect
dc.subject.lcsh Immunological tolerance
dc.subject.lcsh Antigens
dc.title Decreased Lactobacillus populations after erythromycin treatment hinders the induction of oral tolerance to fed ovalbumin en_US
dc.description.degree Thesis (M.S.)
dc.date.liftdate 2012-05-23
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1670056


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  • Master's Theses [5358]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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