Aberrant expression of TAL-1 increases resistance to apoptosis in T-cell acute lymphoblastic leukemia

Cardinal Scholar

Show simple item record

dc.contributor.advisor Olesen, James B.
dc.contributor.author Needler, Gavin U.
dc.date.accessioned 2012-05-31T15:50:52Z
dc.date.available 2012-05-31T15:50:52Z
dc.date.created 2012-05-05
dc.date.issued 2012-05-05
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/123456789/195942
dc.description.abstract T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid disorder that results from an over proliferation of immature lymphocytes in the blood and bone marrow. It has been determined that 60% of patients stricken with T-ALL aberrantly express TAL-1 and have been shown to respond poorly to chemotherapy. This research sought to determine if TAL-1 influences the expression of the Bcl-2 family members Bcl-2 (anti-apoptotic), Bad and Bax (pro-apoptotic). TAL-1 and Bcl-2 levels were elevated while Bad and Bax levels were lower in etoposide-treated Jurkat cells as compared to TRAIL-treated and dual-treated Jurkat cells in which TAL-1 and Bcl-2 levels were lower while Bad and Bax levels were elevated. These results suggest TAL-1 up-regulates Bcl-2 and suppress Bad and Bax expression in response to etoposide treatment, thus inducing an anti-apoptotic response in the cell. These results also suggest that TRAIL and the dual treatment of etoposide and TRAIL down-regulates TAL-1 and Bcl-2 expression while up-regulating Bad and Bax, thus inducing a pro-apoptotic response in the cell.
dc.description.sponsorship Department of Biology
dc.subject.lcsh Etoposide -- Physiological effect.
dc.subject.lcsh Apoptosis -- Genetic aspects.
dc.subject.lcsh Lymphoblastic leukemia -- Genetic aspects.
dc.title Aberrant expression of TAL-1 increases resistance to apoptosis in T-cell acute lymphoblastic leukemia en_US
dc.title.alternative Aberrant expression of T-cell acute lymphoblastic leukemia 1 increases resistance to apoptosis in T-cell acute lymphoblastic leukemia
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1670306


Files in this item

This item appears in the following Collection(s)

  • Master's Theses [5318]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

Show simple item record

Search Cardinal Scholar


Browse

My Account