Effects of ribose supplementation on adenine nucleotide metabolism in human skeletal muscle during high-intensity exercise

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dc.contributor.advisor Trappe, Scott William en_US
dc.contributor.author Gallagher, Philip M. en_US
dc.date.accessioned 2011-06-03T19:25:47Z
dc.date.available 2011-06-03T19:25:47Z
dc.date.created 2000 en_US
dc.date.issued 2000
dc.identifier LD2489.Z68 2000 .G35 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/176309
dc.description.abstract During periods of intense exercise the adenine nucleotide pool in skeletal muscle becomes partially depleted. Ribose has been shown to increase rates of both purine salvage and adenine nucleotide de novo synthesis in rat skeletal muscle. However, to date no research has been conducted on the effects of ribose on adenine nucleotide levels in human skeletal muscle. Therefore, the purpose of this investigation was to determine the effects of ribose supplementation on adenine nucleotide levels in human skeletal muscle during high-intensity exercise. To do this, an 11-day supplementation of either ribose (20 g.d-1) or placebo (glucose 20 g•d-1) was given to 16 healthy male subjects. After 72 hours of supplementation, the subjects performed five-days of high-intensity exercise designed to elicit significant reductions in adenine nucleotides. A 65 hour recovery period was completed following the exercise protocol. Muscle biopsies were performed at four different time points during the supplementation/exercise period.The exercise protocol elicited significant decreases in skeletal muscle adenine nucleotide levels of both the ribose and placebo groups (p<0.05). However, ribose supplementation was shown to partially attenuated the adenine nucleotide decrease. The placebo group demonstrated a 39% decrease, while the ribose group dropped 23% in TAN levels (p<0.05). The largest decreases were observed in ATP for both groups; however, the decreases were significantly greater in the placebo group (p<0.05). Both groups displayed a similar amount of replenishment in adenine nucleotides 65 hours following the 5-day exercise period. No differences were demonstrated in ADP or AMP for either the ribose and placebo groups throughout the investigation. Both groups displayed an increase in E MP post-exercise, but the increase was only significant in the ribose group (p<0.05). No differences in mean power, peak power, and fatigue were observed between the ribose and placebo group. However, the ribose group consistently displayed a non-significantly greater percent change (3.1 %) in mean power. en_US
dc.description.sponsorship School of Physical Education
dc.format.extent xii, 151 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Ribose -- Physiological effect. en_US
dc.subject.lcsh Adenine nucleotides. en_US
dc.subject.lcsh Exercise -- Physiological aspects. en_US
dc.title Effects of ribose supplementation on adenine nucleotide metabolism in human skeletal muscle during high-intensity exercise en_US
dc.description.degree Thesis (Ph. D.) en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1170325 en_US


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  • Doctoral Dissertations [3210]
    Doctoral dissertations submitted to the Graduate School by Ball State University doctoral candidates in partial fulfillment of degree requirements.

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