A study of the Project for American Studies in the Secondary Schools and its effect on curricular change

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dc.contributor.advisor Reak, Jack en_US
dc.contributor.author McNierney, Donna J. en_US
dc.coverage.spatial n-us--- en_US
dc.date.accessioned 2011-06-03T19:28:51Z
dc.date.available 2011-06-03T19:28:51Z
dc.date.created 1983 en_US
dc.date.issued 1983
dc.identifier LD2489.Z64 1983 .M36 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/178362
dc.description.abstract The purposes of this study were to determine the effect of the exogenous polyamines, spermidine and spermidine, on growth of crown gall tumors, to assay levels of spermidine and spermine in normal and crown gall tumor tissue and to determine the effects of selected anti-tumor compounds on growth of crown gall tumors as well as on the endogenous levels of the polyamines in those tumors.Findings1. Spermidine and spermine are present in normal potato tissue and crown gall tumor tissue grown on potato discs.2. Exogenous spermidine and spermine do affect growth of crown gall tumors depending upon the concentration of the solutions added, the type of polyamine added and the number of times the solutions are applied.3. Spermidine (1 mM) has a positive growth effect on crown gall tumors.4. Crown gall tumor tissue contains more spermidine than corresponding normal potato tissue; spermine levels are consistently low compared to spermidine levels in both crown gall tissue and normal potato tissue.5. The level of spermidine in tumor tissue increases as the tumors develop; the level of spermine remains consistently low.6. Addition of methylglyoxal bis (guanylyhdrazone) inhibits tumor growth, but the inhibitory effect is decreased by concurrent administration of spermidine.7. Both novobiocin and nalidixic acid have an inhibitory effect on tumor growth, but the effects are decreased by concurrent administration of spermidine. Reversal of the nalidixic acid effect on growth by addition of spermidine is more pronounced than reversal of the novobiocin effect.8. Methylglyoxal bis (guanylhydrazone) decreases the endogenous levels of both spermidine and spermine in crown gall tumor tissue.Conclusions1. The polyamine, spermidine, plays an important role in the growth of crown gall tumors.2. Compounds which inhibit spermidine biosynthesis or the possible mode of action of spermidine inhibit tumor growth.3. Other polyamines appear to have no significant role in crown gall tumor growth.4. The growth of crown gall tumors involves the activation of a mechanism leading to the increased biosynthesis of spermidine.5. A specific inhibitor of polyamine biosynthesis in animals also reduces endogenous levels of spermidine and spermine in crown gall tumors.6. These data further support the hypothesis that crown gall tumors are similar to animal tumors. en_US
dc.format.extent viii, 154 leaves ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Curriculum planning. en_US
dc.subject.other United States -- Study and teaching (Secondary) en_US
dc.title A study of the Project for American Studies in the Secondary Schools and its effect on curricular change en_US
dc.description.degree Thesis (D. Ed.) en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/225255 en_US


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  • Doctoral Dissertations [3248]
    Doctoral dissertations submitted to the Graduate School by Ball State University doctoral candidates in partial fulfillment of degree requirements.

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