Angiotensin conversion in the coronary and hindlamb vasculatures of canines

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dc.contributor.advisor DiSalvo, Joseph en_US
dc.contributor.author Britton, Steven L., 1948- en_US
dc.date.accessioned 2011-06-03T19:30:55Z
dc.date.available 2011-06-03T19:30:55Z
dc.date.created 1972 en_US
dc.date.issued 1972
dc.identifier LD2489.Z78 1972 .B75 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/180595
dc.description.abstract The effects of angiotensinsI and II on pump-perfusion pressure were examined in the hindlimb vasculature and in the vasculature supplied by the circumflex coronary artery in dogs. In both vasculatures angiotensins I and II caused dosedependent increases in perfusion pressure reflecting directionally similar changes in resistance to blood flow. Responses to angiotensin I were blocked with SQ 20881, a nonapeptide that specifically inhibits conversion of angiotensin I to angiotensin II. In contrast, P-113, a specific anglotensin II antagonist, abolished increases in perfusion pressure produced by angiotensins I and II. These results suggest that increases caused by local administration of angiotensin I in hindlimb or coronary vasculatures are largely ascribable to its enzymatic conversion to angiotensin II. Such conversion appears to occur to the extent of 31% in the hindlimb vasculature, and 26% in the coronary vasculature.
dc.format.extent vi, 93 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Blood -- Circulation. en_US
dc.subject.lcsh Cardiovascular system. en_US
dc.title Angiotensin conversion in the coronary and hindlamb vasculatures of canines en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/415884 en_US


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  • Master's Theses [5330]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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