The synthesis and identification of penicilloyl-polycysteine allergy

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dc.contributor.advisor Wagner, Eugene S. en_US
dc.contributor.author Storhoff, Diana F., 1946- en_US
dc.date.accessioned 2011-06-03T19:31:15Z
dc.date.available 2011-06-03T19:31:15Z
dc.date.created 1974 en_US
dc.date.issued 1974
dc.identifier LD2489.Z78 1974 .S76 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/180898
dc.description.abstract Benzylpenicilloyl-poly-L-cysteine is prepared by reacting benzylpenicillenic acid with poly-L-cysteine at 370° in water at pH 8.3 or buffer at pH 7.98. The preparations of penicilloyl-cysteine, S-acetamidomethyl-polycysteine, and S-acetamidomethyl-penicilloyl-polycysteine are also described. C14-labeling and penamaldate assays are used to determine penicilloyl content. The iodoacetic acid method is used to ascertain thiol content.The ultraviolet spectra for penicilloyl-polycysteine, pencilloyl-cysteine, poly-L-cysteine, poly-S-carbobenzoxy-L-cysteine, S-acetamidomethyl-polycysteine and S-acetamidomethyl-penicilloyl-polycysteine are reported. The infrared spectra of penicilloyl-polycysteine, penicilloyl-cysteine, poly-S-carbobenzoxy-L-cysteine, S-acetamidomethyl-polycysteine, and S-acetamidomethyl-penicilloyl-polycysteine are reported. The nmr spectra of poly-L-cysteine, penicilloyl-cysteine, S-acetamidomethyl-polycysteine, and S-acetamidomethyl-penicilloyl-polycysteine are discussed.The kinetic rates of reaction of benzylpenicillenic acid at 37.5 ± 0.50 in buffer, cysteine, N, S-di-CBZ L-cysteine, poly-L-cysteine, poly-S-CBZ L-cysteine andβ-mercaptoethylamine are compared.Ball State UniversityMuncie, IN 47306 en_US
dc.format.extent vi, 63 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Penicillin. en_US
dc.subject.lcsh Drug allergy. en_US
dc.subject.lcsh Skin tests. en_US
dc.subject.other Ball State University. Thesis (M.S.) en_US
dc.title The synthesis and identification of penicilloyl-polycysteine allergy en_US
dc.description.degree Thesis (M.S.)--Ball State University, 1974. en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/416928 en_US


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  • Master's Theses [5330]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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