Skeletal muscle fiber composition in selected isogenic strains of mice

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dc.contributor.advisor Engstrom, Lee E. en_US Faulkner, Robert F. en_US 2011-06-03T19:31:37Z 2011-06-03T19:31:37Z 1976 en_US 1976
dc.identifier LD2489.Z78 1976 .F38 en_US
dc.description.abstract The objective of this research was to compare the skeletal muscle fiber composition in selected isogenic strains of mice. Six strains of mice were surveyed, one male and one female from each strain. The gastrocnemius and quadriceps muscles were stained for oxidative and glycolytic activities as well as contractile properties by using five histochemical stains. These results indicated that both muscles were composed predominantly of fast glycolytic (FG) and fast oxidativeglycolytic (FOG) fibers. There were few slow oxidative (SO) fibers which were mostly confined to the red portion of each muscle, although in some mice (0113 C57BL/6J black male, 0119 DBA/2J dilute brown female, and 0105 BALB/cJ albino male and female) this fiber type seemed to be lacking completely in one or both muscles surveyed. In addition, it was found through 2 the use of planimetry, that SO fibers (-x = 1140.97 μ2) were significantly smaller (P<0.01) than the FOG and FG fibers (-x = 1514.08μ2).Within the limits of these observations it is concluded that further examination of these strains of mice is necessary in order to better facilitate a quantitative genetic analysis. Moreover, developmental and environmental studies would serve to clarify the genetic influences on muscle fiber composition.
dc.format.extent vii, 45 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Muscles. en_US
dc.subject.lcsh Musculoskeletal system. en_US
dc.title Skeletal muscle fiber composition in selected isogenic strains of mice en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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