A comparison of selected enzyme activities in normal and tumorous mouse mammary tissue

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dc.contributor.advisor Bennett, Alice S. en_US
dc.contributor.author Kofski, Michael Lee en_US
dc.date.accessioned 2011-06-03T19:32:32Z
dc.date.available 2011-06-03T19:32:32Z
dc.date.created 1979 en_US
dc.date.issued 1979
dc.identifier LD2489.Z78 1979 .K63 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/182010
dc.description.abstract The activities of phosphohexose isomerase (EC. 5.3.1.9), isocitrate dehydrogenase (EC. 1.1.1.42) and lactate dehydrogenase (EC. 1.1.1.27) were measured in 14 normal and 21 tumorous mouse mammary tissue samples. Methods of tissue extraction and activity determination in this study employed equipment found in most clinical laboratories.For each of the three enzymes there was a statistically significant (p <.05) elevation of the tumor sample group's activities. The activities of the normal tissues were: PHI x = 9.6 and SD = 4.6, ICD x = 13.2 and SD = 5.3, and IDH x = 10.9 and SD = 5.3. The activities of the tumorous tissues were: PHI x = 55.2 and SD = 29.9, ICD x = 40.5 and SD = 23.8, and IDH x = 55.8 and SD = 31.4.Using values of 20, 27, and 21 for the upper limit of normal activity (x + 2SD) for PHI, ICD, and LDH respectively, the tissue samples can be divided into normal and tumorous groups with l00% sensitivity and 85% specificity.Ball State UniversityMuncie, IN 47306 en_US
dc.format.extent 27 leaves ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Breast -- Cancer -- Animal models. en_US
dc.subject.lcsh Enzymes. en_US
dc.subject.lcsh Mammary glands -- Tumors. en_US
dc.subject.lcsh Mice -- Diseases. en_US
dc.subject.other Ball State University. Thesis (M.S.) en_US
dc.title A comparison of selected enzyme activities in normal and tumorous mouse mammary tissue en_US
dc.description.degree Thesis (M.S.)--Ball State University, 1979. en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/225589 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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