Intracellular signaling, sarcopenia, and exercise

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dc.contributor.advisor Trappe, Scott William en_US Williamson, David L. en_US 2011-06-03T19:32:33Z 2011-06-03T19:32:33Z 2002 en_US 2002
dc.identifier LD2489.Z68 2002 .W55 en_US
dc.description.abstract The purpose of this investigation was to examine differences under resting conditions (baseline) and after a bout of resistance exercise, in the total amount and the activation (phosphorylation) of the p42/44 MAPK signaling cascade proteins (ERK 1/2, p90RSK, and MNK 1) in young and old men. Eight young (22±1 yr) and eight old (79±3 yr) men underwent a resting muscle biopsy of the vastus lateralis, then a knee extensor resistance exercise session (29 contractions at -70% of max), followed by a post-exercise biopsy. The total protein expression and phosphorylation state for ERK 1/2, p90RSK, and MNK 1 was determined by Western immunoblot analysis. Total protein expression of ERK 1/2 and MNK 1 were not different between the young and old, before and after exercise. The resistance exercise bout caused an increase in phosphorylation of the ERK 1/2, p90RSK, and MNK 1 proteins (73, 95, and 61%, respectively; P<0.05) in the young men. Conversely, the older men showed a decrease in ERK 1/2, p90RSK, and MNK1 phosphorylation (-48, -62, and -37%, respectively; P<0.05) after the exercise bout (versus old pre). Although, the old men displayed higher pre-exercise phosphorylation of these proteins versus young pre-exercise (131, 248, and 74%, respectively; P<0.05). This investigation is the first to provide evidence that MAPK signaling pathways differentially respond under resting and exercise conditions in skeletal muscle of young and old men. These findings may have implications for other processes (e.g. transcription and translation) involved in skeletal muscle type and growth, when examining the changes occurring with aging muscle before and after resistance exercise/training. en_US
dc.description.sponsorship School of Physical Education
dc.format.extent x, 105 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Exercise tests. en_US
dc.subject.lcsh Exercise -- Physiological aspects. en_US
dc.subject.lcsh Muscle proteins -- Effect of exercise on. en_US
dc.subject.lcsh Older men -- Effect of exercise on. en_US
dc.subject.lcsh Exercise for older people. en_US
dc.title Intracellular signaling, sarcopenia, and exercise en_US Thesis (Ph.D.) en_US
dc.identifier.cardcat-url en_US

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  • Doctoral Dissertations [3248]
    Doctoral dissertations submitted to the Graduate School by Ball State University doctoral candidates in partial fulfillment of degree requirements.

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