Investigations of the interactions of benzylpenicilloic acid with human erythrocytes ; and, RCHDCHDX compounds as stereochemical probes : MINDO/3 and MNDO investigations of conformational preferences in RCHb2sCHb2sX compounds

Cardinal Scholar

Show simple item record

dc.contributor.advisor Wagner, Eugene S. en_US
dc.contributor.author Wihebrink, W. Scott en_US
dc.contributor.other Wihebrink, W. Scott. RCHDCHDX compounds as stereochemical probes. en_US
dc.date.accessioned 2011-06-03T19:33:11Z
dc.date.available 2011-06-03T19:33:11Z
dc.date.created 1982 en_US
dc.date.issued 1982
dc.identifier LD2489.Z78 1982 .W53 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/182523
dc.description.abstract Benzylpenicillin was found to migrate irreversibly into human erythrocytes. No detectable amounts of penicillin bind to the erythrocyte membrane. After migration into the cell, benzylpenicillin is hydrolyzed into benzylpenicilloic acid, which can not migrate out of the cell. DNDS did not affect the appearance of benzylpenicilloic acid in the erythrocyte, therefore showing that: 1) benzylpenicillin does not hydrolyze to benzylpenicilloic acid in the incubation mixture then migrate to the cell, 2) benzylpenicillin migrates into the erythrocyte and is hydrolyzed to benzylpenicilloic acid. Benzylpenicilloic acid does not migrate into erythrocytes.Ball State UniversityMuncie, IN 47306 en_US
dc.format.extent x, 79 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Penicillin -- Physiological effect. en_US
dc.subject.lcsh Stereochemistry. en_US
dc.subject.other Ball State University. Thesis (M.S.) en_US
dc.title Investigations of the interactions of benzylpenicilloic acid with human erythrocytes ; and, RCHDCHDX compounds as stereochemical probes : MINDO/3 and MNDO investigations of conformational preferences in RCHb2sCHb2sX compounds en_US
dc.title.alternative Investigations of the interactions of benzylpenicilloic acid with human erythrocytes. en_US
dc.title.alternative RCHDCHDX compounds as stereochemical probes. en_US
dc.description.degree Thesis (M.S.)--Ball State University, 1982. en_US
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/388165 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

Show simple item record

Search Cardinal Scholar


Browse

My Account