The staging of mouse breast tumors using a mouse mammary tumor classification system

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dc.contributor.advisor Hendrickson, Donald A. en_US Adams, Rose Anna en_US 2011-06-03T19:33:25Z 2011-06-03T19:33:25Z 1982 en_US 1982
dc.identifier LD2489.Z78 1982 .A32 en_US
dc.description.abstract Since 1942, when Bittner reported the incidence of non-induced tumors occuring in mice, strains of laboratory mice producing mammary carcinomas have been used as tools in research. Although not ideal for human studies, the histological and morophological similarities of the human and mouse mammary glands make it an excellent model to study the development of breast cancer. This study was performed to develop a rapid and consistent classification system for mouse mammary tissue, and compare various tumors to this system.Laboratory mice from the A and Balb/c strains were utilized in these studies. The three types of tumors developed in these mice were, non-induced, induced, and transplanted. Specimens of these tumors were collected and studied via light and electron microscopy for cellularchanges of tumor cells. These tumors were then classified according to the new system. These various tumors ranged from Class 0, which were normal cells, through gradual cellular changes to a Class IV, which were totally undifferentiated cells. host induced and non-induced tumors were Class III or IV, while the transplanted tumors were Class IV. This system facilitated the classification of mouse mammary tumors.
dc.format.extent ii, vi, 49 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Mice. en_US
dc.subject.lcsh Breast -- Cancer. en_US
dc.title The staging of mouse breast tumors using a mouse mammary tumor classification system en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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