S-adenosyl-L-methionine decarboxylase activity in mouse mammary adenocarcinomas and normal mouse mammary tissue

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dc.contributor.advisor Bennett, Alice S. en_US
dc.contributor.author Auger, Elizabeth A. en_US
dc.date.accessioned 2011-06-03T19:33:25Z
dc.date.available 2011-06-03T19:33:25Z
dc.date.created 1982 en_US
dc.date.issued 1982
dc.identifier LD2489.Z78 1982 .A93 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/182676
dc.description.abstract The activity of S-adenosyl-L-methionine Decarboxylase (E. C. 4.1.1.50) was measured in two different normal and five different tumorous mouse mananary tissue samples. The soluble fraction was assayed for SAM decarboxylase activity using 14COOHlabeled SAM as the substrate. The amount of 14002 evolved was measured using a liquid scintillation counter.There was a significant elevation of SAM decarboxylase activity in the tumor sample group. The activities of the tumor tissue was x = 15.62 and SD = 8.24. The activity in the normal samples was too low to measure:These results suggest an increase in not only SAM decarboxylase activity, but also in the levels of spermidine and spermine. These increases are characteristics of cancer cells and may result in changes in enzyme activities and membrane phospholipid composition.
dc.format.extent iii, 26 leaves ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Breast -- Cancer. en_US
dc.subject.lcsh Adenosylmethionine. en_US
dc.subject.lcsh Cancer -- Animal models. en_US
dc.title S-adenosyl-L-methionine decarboxylase activity in mouse mammary adenocarcinomas and normal mouse mammary tissue en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/387349 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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