Abstract:
Lupus anticoagulants (LA) have been identified as antiphospholipid antibodies which can alter certain membrane-related endothelial activities, resulting in increased thrombogenesis. The effects of LA-containing patient plasmas on selected thrombosis-related endothelial functions were examined; 68% of 25 patient plasmas exhibited significant antiphospholipid antibody (APA) IgG and/or IgM directed against one of the four phospholipids tested in vitro; 44% exhibited anti-endothelial antibody. Eighty percent of plasmas with anti-endothelial IgM exhibited APA reactive with phosphatidyl inositol; antiphospholipid IgG did not correlate well with antiendothelium IgG. Patient plasmas that significantly stimulated EC PGI2 secretion uniformly exhibited anti-phosphatidyl serine IgM.Multiple mechanisms of induction of LA, and strong association of anti-PS and anti-EC antibody with thrombosis and related disorders were observed.Ball State UniversityMuncie, IN 47306