Carnitine palmitoyltransferase activity in the aging rat

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dc.contributor.advisor Craig, Bruce W. en_US Sites, Dawn L. en_US 2011-06-03T19:34:57Z 2011-06-03T19:34:57Z 1989 en_US 1989
dc.identifier LD2489.Z78 1989 .S56 en_US
dc.description.abstract In an effort to determine the metabolic changes that occur in fatty acid oxidation during the rapid growth period, the activity of carnitine palmitoyltransferase was measured in four groups of animals at 4, 8, 12 and 16 weeks of age.Muscle samples were taken from the soleus after animals were anesthesi2ed, and the samples were assayed for CPT activity. The CPT activity was significantly higher at 4 weeks than at 8, 12 and 16 weeks (p0.0001), and the fl week activity was significantly higher that the 16 week animals. It was found that there were two distinct phases of decline in CPT activity. The first occured from 4-8 weeks where a 74% drop in activity was recorded. The second phase was a more gradual decline that occured after 8 weeks. 21% decline in activity occured between 8 and 12 weeks, followed by a 23% decrease after 12 weeks. The first drastic drop in activity can be attributed to the residual heightened enzyme concentration carried over from the suckling period in which the rat was exposed to a high fat diet found in the mother's milk. The second phase of the decline in activity is due to a dietary change which caused a shift in metabolism from fat to glucose as the primary carbon source for fuel.
dc.description.sponsorship School of Physical Education
dc.format.extent v, 47 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Fatty acids -- Metabolism. en_US
dc.subject.lcsh Aging -- Physiological aspects. en_US
dc.title Carnitine palmitoyltransferase activity in the aging rat en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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