Hormone-stimulated lipolysis in the aging rat

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dc.contributor.advisor Craig, Bruce W. en_US
dc.contributor.author Skolnick, Sara A. en_US
dc.date.accessioned 2011-06-03T19:34:58Z
dc.date.available 2011-06-03T19:34:58Z
dc.date.created 1989 en_US
dc.date.issued 1989
dc.identifier LD2489.Z78 1989 .S58 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/183733
dc.description.abstract The normal development of adipose tissue lipolysis as measured by glycerol release was studied in epididymal fat pads of Sprague-Dawley rats between 4 and 16 weeks of age and correlated with changes in fat cell size.For each age group studied, 4 weeks, 8 weeks, and 16 weeks of age, basal (no hormone present) and hormone stimulated lipolytic activity were observed for two concentrations of epinephrine were used, maximal (10,00 nM) and minimal (10 nM). Basal levels of glycerol were not linear. There was an increase between 4 and 8 weeks of age followed by a decrease between 8 and 16 weeks of age. The maximal dosage of hormone evoked a large increase in 9lYcerol production between 4 and 8 weeks, which was followed by a decrease between 8 and 16 weeks of age. The minimal dosage of epinephrine, although not significant, showed a decrease in glycerol production from 4 to 16 weeks of age. Fat cell size continued to increase between 4 and 16 weeks. Both fat cell diameter and volumes underwent a linear increase with age. However, the change was not reflected in epinephrine stimulated glycerol release. Therefore, glycerol release is inversely correlated with fat cell size during early development.The results indicate that age influences hormone stimulated lipolysis and is not dependent on cell size. Although the mechanism for the decreased lipolytic response of the isolated adipocytes was not discovered, it is believed that it may be due in part to a reduced number of receptors and to a reduced sensitivity of the cellular enzymatic system underlying lipolysis.
dc.description.sponsorship School of Physical Education
dc.format.extent viii, 51 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Lipolysis. en_US
dc.subject.lcsh Adipose tissues. en_US
dc.subject.lcsh Aging -- Physiological aspects. en_US
dc.subject.lcsh Fat cells. en_US
dc.title Hormone-stimulated lipolysis in the aging rat en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/562784 en_US


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  • Master's Theses [5330]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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