The effects of streptozotocin-induced diabetes on control of serum cholesterol levels in female strain A/ST mice

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dc.contributor.advisor Bennett, Alice S. en_US Esche, Curtis A. en_US 2011-06-03T19:35:37Z 2011-06-03T19:35:37Z 1991 en_US 1991
dc.identifier LD2489.Z78 1991 .E83 en_US
dc.description.abstract Diabetics often have elevated levels of serum lipids and cholesterol and increased risk of cardiovascular disease. Streptozotocin-induced diabetes was used to determine whether elevated serum cholesterol levels in diabetics are due to loss of control of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the committed step in cholesterol synthesis. Strain A/ST female mice were fed 10% corn oil diets, half with 2% cholesterol. Experimental groups were injected with 9.0 mg streptozotocin / 100g body weight. Diabetes was confirmed by weight loss, elevated blood sugars, and enlarged spleens. Reductase activity was assayed spectrophotometrically. Serum cholesterol levels were determined by gas liquid chromatography. Both diabetic and control mice fed cholesterol had elevated serum cholesterol levels and decreased reductase activities. These observations suggest that HMG CoA reductase is not the primary control point in the control of serum cholesterol levels in diabetic mice. The increase in serum cholesterol in the SI mice was not more than in the control group, suggesting that increased serum cholesterol is not a key factor in the control of coronary heart disease and related diseases in diabetics. The HMG CoA reductase activity was reduced in both SI and control mice fed 2% cholesterol, but not significantly, possibly due to a small sample size. Other substances that control serum cholesterol are all density classes of lipoproteins (high, intermediate, low, and very low) as well as the chylomicrons.
dc.description.sponsorship Department of Biology
dc.format.extent iv, 56 leaves ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Hydroxymethylglutaryl coenzyme A reductases. en_US
dc.subject.lcsh Blood cholesterol. en_US
dc.subject.lcsh Diabetic angiopathies. en_US
dc.title The effects of streptozotocin-induced diabetes on control of serum cholesterol levels in female strain A/ST mice en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5330]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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