Effect of dietary fatty acids on the activity of phospholipase C in tumors and livers of strain A/ST mice

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dc.contributor.advisor Bennett, Alice S. en_US
dc.contributor.author Shaffer, Lauren A. en_US
dc.date.accessioned 2011-06-03T19:35:39Z
dc.date.available 2011-06-03T19:35:39Z
dc.date.created 1991 en_US
dc.date.issued 1991
dc.identifier LD2489.Z78 1991 .S53 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/184140
dc.description.abstract Phospholipase C mediated hydrolysis of the phosphoinositides yields second messenger products which have been linked to normal and abnormal cell growth processes. It has been suggested that fatty acids may regulate phospholipase C activity in vivo. This study sought to investigate relationships between phospholipase C activity, tumor size and dietary linoleic and stearic acids.Phospholipase C activity, of livers and serially transplanted mammary adenocarcinomas from female strain A/ST mice on one of three diets, was measured. Tumors ranged from .20 to 2.98 g at the time of removal. Phospholipase C activity of tumors was negatively and significantly (p<.Ol) correlated to increasing tumor weight in those diet groups that contained linoleic acid and no added stearic acid. The highest PLC activity was seen in small tumors across all diet groups. Maximum PLC activity of tumors was over 2 fold higher than the maximum activity of livers across all diet groups. PLC activity of the liver was negatively and significantly (p<.02) correlated to increasing tumor weight for samples from the high linoleic acid diet (SF-15). This research concludes that PLC activity varies during tumorigenesis and may reflect tumor development.
dc.description.sponsorship Department of Biology
dc.format.extent v, 56 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Fatty acids. en_US
dc.subject.lcsh Phospholipases. en_US
dc.subject.lcsh Tumors -- Growth. en_US
dc.subject.lcsh Mice -- Physiology. en_US
dc.title Effect of dietary fatty acids on the activity of phospholipase C in tumors and livers of strain A/ST mice en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/834508 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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