The production of IL-2, IL-4, and TNF-gas in murine leishmaniasis

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dc.contributor.advisor Behforouz, Nancy en_US
dc.contributor.author Green, Lisa J. en_US
dc.date.accessioned 2011-06-03T19:35:45Z
dc.date.available 2011-06-03T19:35:45Z
dc.date.created 1991 en_US
dc.date.issued 1991
dc.identifier LD2489.Z78 1991 .G74 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/184203
dc.description.abstract Prophylactic administration of the immunosuppressive drug cyclosporine A protects Balb/c mice from fatal Leishmania major infections. It is believed that distinct subpopulations of CD4+ T lymphocytes and their distinctive cytokines may determine susceptibility and resistance to leishmaniasis among inbred strains of mice. CsA may enhance disease resistance in Balb/c mice by modulating these T cell subsets and/or their cytokines. We have measured lymphoid cell production of IL-2, IL-4, and TNF-a in naturally resistant C57/Bl/6, CsA-treated Balb/c, and nontreated Balb/c mice during the course of L. major infection. CsA treatment inhibited IL-2 and IL-4 production for the first week of infection. Thereafter the cytokine production of all three groups of mice did not differ greatly except in week two when the treated mice produced significantly enhanced levels of IL-4. C57B1/6 mice did produce slightly more TNF-a than either group of Balb/c mice, but as the CsAprotected and diseased Balb/c mice produced similar amounts of this cytokine, the elevation in C57B1/6 animals probably reflects a strain-related difference rather than disease resistance.
dc.description.sponsorship Department of Biology
dc.format.extent vii, 88 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Leishmaniasis. en_US
dc.subject.lcsh Veterinary protozoology. en_US
dc.subject.lcsh Cyclosporine. en_US
dc.subject.lcsh Immune response -- Regulation. en_US
dc.title The production of IL-2, IL-4, and TNF-gas in murine leishmaniasis en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/774758 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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