Phospholipase c activity in retinal pigment epithelium

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dc.contributor.advisor Meyertholen, Edward P. en_US Donahue, Vicki S. en_US 2011-06-03T19:38:03Z 2011-06-03T19:38:03Z 1997 en_US 1997
dc.identifier LD2489.Z78 1997 .D66 en_US
dc.description.abstract The role of the retinal pigment epithelial cells on the viability and renewal of photoreceptors has been well demonstrated in the Royal College of Surgeons (RCS) strain of rat. These rats are characterized by an inherited time-dependent degeneration of their photoreceptors. This degeneration is apparently due to the inability of the retinal pigment epithelial cells to adequately ingest fragments of photoreceptor membrane that are shed during the course of photoreceptor membrane renewal. The buildup of photoreceptor material in the interphotoreceptor space ultimately leads to the degeneration of photoreceptors in these animals. With regard to the pigment epithelial cells, neither the mechanism mediating the ingestion process in normal rats nor the nature of the defect of this process in RCS rats is understood.It is the goal of this proposed research to assay for the presence of phospholipase C in retinal pigment epithelial (RPE) cells and to determine possible modulators of the enzyme in an attempt to associate this with the process of phagocytosis.
dc.description.sponsorship Department of Biology
dc.format.extent iv, 47 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Visual pigments. en_US
dc.subject.lcsh Epithelium. en_US
dc.subject.lcsh Photoreceptors. en_US
dc.subject.lcsh Retinal degeneration. en_US
dc.subject.lcsh Rats -- Physiology. en_US
dc.title Phospholipase c activity in retinal pigment epithelium en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5358]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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