Effects of dietary stearic and linoleic acid on mammary carcinogenesis and longevity of aging strain A/ST mice

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dc.contributor.advisor Bennett, Alice S. en_US
dc.contributor.author Rogers, Wendy J. en_US
dc.date.accessioned 2011-06-03T19:38:13Z
dc.date.available 2011-06-03T19:38:13Z
dc.date.created 1998 en_US
dc.date.issued 1998
dc.identifier LD2489.Z78 1998 .R64 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/186154
dc.description.abstract This investigation studies the effects of diets containing varying amounts of linoleic acid (a polyunsaturated fatty acid) and stearic acid (a saturated fatty acid) on tumorigenesis, weight and longevity in strain A/ST mice. Linoleic acid [ 18 carbons and 2 double bonds (18:2)] was chosen to represent a fatty acid known to enhance tumorigenesis and obesity in certain strains of mice. Stearic acid [ 18 carbons and no double bonds (18:0)] represents a saturated fatty acid known to increase the latency period for mammary tumor development and to decrease the rate of tumor growth. This study was conducted to determine whether the effects of fatty acids observed in younger mice on time to tumor, survival and body weights were also found in aging animals. Further, by varying the amount of linoleic acid in the diet, this study examined whether the tumor enhancing effects of increasing amounts of linoleic acid could be overcome by the incorporation of dietary stearic acid. All diets had equal percentages, by weight, of protein, salt, sucrose, mineral salt, and vitamin levels and an equal number of calories per gram of food. The SF diet was rich in linoleic acid. The SA-1 diet contained enough linoleic acid to prevent essential fatty acid deficiency, and the SA-4 diet contained the maximal amount of linoleic acid for tumor enhancement. Total body weight and tumor production in the three dietary groups show a relationship between an increase in body weight and tumor production as the amount of dietary linoleic acid increases. There also is an inverse relationship between animal survival and body weight as the amount of dietary linoleic acid increases. Survival thus appears to be dependent on tumor production in the three dietary groups, where there appears to be an inverse relationship between survival and time to tumor as the amount of dietary linoleic acid increases at each timepoint. These results suggest that the inclusion of stearic acid in the diet can, in part, overcome this enhancing effect of linoleic acid, even at the optimal tumor producing level of linoleic acid. The results of this study indicate that that effects of linoleic and stearic acid in aging mice are similar to those in younger animals.
dc.description.sponsorship Department of Biology
dc.format.extent iii, 47 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Breast -- Cancer -- Nutritional aspects. en_US
dc.subject.lcsh Fatty acids. en_US
dc.subject.lcsh Mice -- Longevity. en_US
dc.subject.lcsh Diet in disease. en_US
dc.title Effects of dietary stearic and linoleic acid on mammary carcinogenesis and longevity of aging strain A/ST mice en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1115733 en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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