Age-related changes in kidney function in female pigmented Royal College of Surgeons (RCS) rats

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dc.contributor.advisor Zamlauski-Tucker, Marianna J. en_US Minchev, Kiril M. en_US 2011-06-03T19:39:07Z 2011-06-03T19:39:07Z 2000 en_US 2000
dc.identifier LD2489.Z78 2000 .M556 en_US
dc.description.abstract The Royal College of Surgeons (RCS) rat is an established animal model used to study human retinal dystrophies. This study investigated whether kidney dysfunction accompanies the eye abnormalities seen in this model. Overnight urine collection procedures were used to measure protein excretion in 2, 12, and 22 month old female pigmented RCS rats and control rats (RDY). Clearance experiments were performed in anesthetized rats to measure glomerular filtration rate (GFR) and renal plasma flow rate (RPF). There was an age-related increase in protein excretion in both RCS and RDY rats, but the protein excretion was significantly higher in the RCS rats at 2 and 22 months of age. Whole kidney GFR and RPF were significantly lower in the 22 month old RCS rats, when compared to age-matched RDY rats. These findings suggest that the RCS rat exhibits both kidney and eye abnormalities.
dc.description.sponsorship Department of Physiology and Health Science
dc.format.extent iv, 45 leaves : col. ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Rats -- Anatomy. en_US
dc.subject.lcsh Kidneys -- Abnormalities -- Age factors. en_US
dc.subject.lcsh Retinal degeneration. en_US
dc.title Age-related changes in kidney function in female pigmented Royal College of Surgeons (RCS) rats en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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