Synthesis of 4-alkyl-3,5-diamino-1-phenylpyrazoles

Cardinal Scholar

Show simple item record

dc.contributor.advisor Sammelson, Robert E. en_US
dc.contributor.author Dunham, Jason C. en_US
dc.date.accessioned 2011-06-03T19:41:14Z
dc.date.available 2011-06-03T19:41:14Z
dc.date.created 2006 en_US
dc.date.issued 2006
dc.identifier LD2489.Z78 2006 .D86 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/188237
dc.description.abstract The goal of this project is to synthesize and purify a library of novel 4-alkyl-3,5-diamino-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazoles. These molecules are similar to other fiproles, which have been shown by Sammelson et al. to have pesticidal activities at the GABA receptor.' Fiproles are analogues of Fipronil, a very important pesticide. Replacing the cyano group normally located at the 3-position of the pyrazole ring with an amino group will change the binding potency of the phenylpyrazoles. Changes in binding produced by the changes introduced in molecular structure can create more information about the GABA receptor.Synthesis of our target compounds starts with production of monosubstituted malononitriles. Conventionally a two-step process, our research developed a new, efficient one-step process using borohydride as the only reagent. We utilized this method in the synthesis of desired monosubstituted malononitriles. These were converted to unsymmetrical disubstituted malononitriles, and to our target fiprole compounds, through a 4-alkyl-3,5-diaminopyrazole intermediate.
dc.description.sponsorship Department of Chemistry
dc.format.extent iv, 125 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Pyrazoles -- Synthesis. en_US
dc.subject.lcsh Phenyl compounds -- Synthesis. en_US
dc.subject.lcsh GABA -- Receptors. en_US
dc.title Synthesis of 4-alkyl-3,5-diamino-1-phenylpyrazoles en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1339144 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

Show simple item record

Search Cardinal Scholar


Browse

My Account