A model for examining antinuclear antibody circulation and binding capabilities of human serum from systemic lupus erythematosus patients

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dc.contributor.advisor Kelly-Worden, Marie L. en_US
dc.contributor.author Griffin, Marley A. en_US
dc.date.accessioned 2011-06-03T19:41:15Z
dc.date.available 2011-06-03T19:41:15Z
dc.date.created 2007 en_US
dc.date.issued 2007
dc.identifier LD2489.Z78 2007 .G75 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/188241
dc.description.abstract Antinuclear antibodies (ANA) are used in screening and diagnosis of autoimmune connective tissue disorders including systemic lupus erythematosus (SLE). CNS related disorders are prevalent in SLE patients (–80%) and ANA binds specific sites within the brain. To investigate ANA infiltration across the blood-brain barrier (BBB), an ANA injectable Lewis rat model was created using 3 rat groups (saline, ANA, and ANA with histamine; since histamine promotes BBB permeability). ANA serum levels were tested for all three rat groups and rats injected with histamine demonstrated signs of histadelia. Brain slices were obtained and examined for the presence of ANA using immunofluorescence. ANA infiltration across the BBB was observed in ANA injected groups. Though the ANA and ANA histamine groups were significantly different from controls (p<0.034, p<0.030, respectively), no significance between ANA and ANA histamine groups was observed. This model could further be used to examine BBB permeability and potential drug therapy.
dc.description.sponsorship Department of Physiology and Health Science
dc.format.extent vi, 36 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Antinuclear factors -- Physiological effect. en_US
dc.subject.lcsh Blood-brain barrier. en_US
dc.subject.lcsh Systemic lupus erythematosus -- Animal models. en_US
dc.title A model for examining antinuclear antibody circulation and binding capabilities of human serum from systemic lupus erythematosus patients en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1371840 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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