The effect of a cyclooxygenase-2 inhibitor on human mixed muscle protein synthesis after acute resistance exercise

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dc.contributor.advisor Trappe, Todd A. en_US Burd, Nicholas A. en_US 2011-06-03T19:41:18Z 2011-06-03T19:41:18Z 2007 en_US 2007
dc.identifier LD2489.Z78 2007 .B87 en_US
dc.description.abstract We have previously shown that non-specific blockade of the cyclooxygenase (COX) enzymes in skeletal muscle eliminates the normal increase in muscle protein synthesis following resistance exercise. The current study tested the hypothesis that this COX-mediated increase in postexercise muscle protein synthesis is specifically regulated by the COX-2 isoform. Sixteen males (23 ± 1 yr, 177 ± 2 cm, 81.5 ± 3.4 kg) were randomly assigned to one of two groups that received three doses of either a specific COX-2 inhibitor (celecoxib; 200 mg per dose, 600 mg total) or a placebo during the 24 hours following a single bout of resistance exercise with the knee extensors. Skeletal muscle fractional synthesis rate (FSR) was measured at rest and 24 hours postexercise using a primed constant infusion of [2H5]phenylalanine coupled with muscle biopsies of the vastus lateralis. Mixed muscle FSR was increased following exercise to a greater extent (206%, P<0.05) in the COX-2 group (0.052 ± 0.014 %Ih) as compared with the placebo group (0.017 ± 0.007 %Ih). These results suggest that the specific inhibition of the COX-2 isoform in human skeletal muscle causes a compensatory response in muscle protein synthesis. These data also highlight the involvement of the cyclooxygenase pathways in the regulation of muscle protein synthesis following resistance exercise.
dc.description.sponsorship School of Physical Education, Sport, and Exercise Science
dc.format.extent vii, 114 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Cyclooxygenase 2 -- Inhibitors -- Physiological effect. en_US
dc.subject.lcsh Muscle proteins -- Synthesis. en_US
dc.subject.lcsh Isometric exercise -- Physiological aspects. en_US
dc.title The effect of a cyclooxygenase-2 inhibitor on human mixed muscle protein synthesis after acute resistance exercise en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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