The fibrinolytic response to acute resistance training in lean and obese women

Cardinal Scholar

Show simple item record

dc.contributor.advisor Nagelkirk, Paul R. en_US Pfeiffer, Rebecca L. en_US 2011-06-03T19:41:36Z 2011-06-03T19:41:36Z 2007 en_US 2007
dc.identifier LD2489.Z78 2007 .P49 en_US
dc.description.abstract Fibrinolysis is the process by which fibrin blood clots are dissolved. Fibrinolytic research is clinically relevant because decreased fibrinolytic potential is linked to increased risk of an ischemic event. Fibrinolysis is known to increase in response to aerobic exercise, however, few research studies have focused on the fibrinolytic response to resistance exercise. Furthermore, women are severely underrepresented in fibrinolytic research, and there are no current studies that focus on women and resistance exercise. Estrogen has been shown to affect basal fibrinolytic potential resulting in the need for fibrinolytic research focused on female subjects. Body composition is known to influence basal fibrinolysis leaving individuals with higher absolute amounts of body fat at risk for cardiovascular events due to decreased fibrinolytic potential. Little is known, however, about the influence of body composition on the fibrinolytic response to exercise. Purpose. The purpose of this study was to describe the fibrinolytic response to acute resistance training in young women, and further, to determine how body fat percentage affects fibrinolysis at rest and following resistance exercise. Methods. Twenty-three sedentary, healthy women (22.5 ± 4 yrs, 22.3 ± 3.0 kg•m 2) participated in the study. Body fat percentage and fat distribution were assessed using dual-energy X-ray absorptiometry (DEXA), and subjects were separated into two groups by body fat percentage: <30% (lean, n=12) and >30% (obese, n=11). Each subject performed 6 sets of 10 leg extension repetitions at an intensity associated with 70% of her one-repetition maximum. The two primary mediators of fibrinolytic potential, tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1(PAI-1), were assessed at baseline and immediately after exercise in venous blood. Results. tPA activity increased in response to acute resistance exercise (p<0.05), however, there was no significant change in PAI-1 activity (p>0.05). A significant main effect of group was observed, indicating the lean women had higher tPA activity (p<0.05) and lower PAI-1 activity (p<0.05) than the obese group. A significant time x group interaction indicated that the tPA response was blunted in the obese group (p<0.05). Conclusions. Fibrinolytic potential increases in response to acute resistance exercise in young women due to increases in tPA activity. Obese women demonstrate a decreased fibrinolytic potential at rest and following acute resistance exercise compared to lean women. Given the relationship between fibrinolytic potential and outcomes of cardiovascular disease, these physiological responses suggest that overweight women may be at elevated risk of an adverse cardiovascular event both at rest and during exercise.
dc.description.sponsorship School of Physical Education, Sport, and Exercise Science
dc.format.extent v, 64 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Fibrinolysis. en_US
dc.subject.lcsh Isometric exercise -- Physiological aspects. en_US
dc.subject.lcsh Women -- Physiology. en_US
dc.subject.lcsh Overweight women -- Physiology. en_US
dc.title The fibrinolytic response to acute resistance training in lean and obese women en_US Thesis (M.S.)
dc.identifier.cardcat-url en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

Show simple item record

Search Cardinal Scholar


My Account