Examination of the involvement of the Stat6-regulated genes, Gfi-1 and Gfi-1b, in the development of a lymphoproliferative disease in mice

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dc.contributor.advisor Bruns, Heather A. en_US
dc.contributor.author Stephenson, Nicole E. en_US
dc.date.accessioned 2011-06-03T19:41:48Z
dc.date.available 2011-06-03T19:41:48Z
dc.date.created 2008 en_US
dc.date.issued 2008
dc.identifier LD2489.Z78 2008 .S74 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/188484
dc.description.abstract Mouse models (that develop or can be stimulated to develop lymphomas) are used to examine cancer-related processes. Mouse models can be effective tools used to identify new, early, and pre-malignant markers of lymphomas. Signal Transducer and Activator of Transcription (STAT) 6 is a transcription factor activated through the Jak-Stat pathway. Transgenic mice expressing a constantly activated Stat6 (Stat6VT) were previously generated and characterized to have altered lymphocyte homeostasis. Some of these Stat6VT mice developed a lymphoproliferative disorder (LPD). LPD, including lymphomas, develops when lymphocytes are overproduced or act abnormally. These Stat6VT mice may serve as a model for examining lymphoma development. In order to characterize the altered lymphocytes and determine if LPD observed in the Stat6VT mice is characteristic of lymphoma, RT-PCR analysis and Western analysis were done to examine if the presence of Stat6VT alters the expression of the cell cycle genes Gfi-1 and Gfi-1b and if these genes differ in LPD Stat6VT verses control mice.
dc.description.sponsorship Department of Biology
dc.format.extent x, 46 leaves : ill. (some col.) ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Transcription factors. en_US
dc.subject.lcsh Lymphoproliferative disorders -- Genetic aspects. en_US
dc.subject.lcsh Lymphoproliferative disorders -- Animal models. en_US
dc.title Examination of the involvement of the Stat6-regulated genes, Gfi-1 and Gfi-1b, in the development of a lymphoproliferative disease in mice en_US
dc.description.degree Thesis (M.S.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1391679 en_US


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  • Master's Theses [5510]
    Master's theses submitted to the Graduate School by Ball State University master's degree candidates in partial fulfillment of degree requirements.

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