The induction of cardiac hypertrophy in mice and the subsequent protein analyses of the heart tissue : an honors thesis (HONRS 499)

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dc.contributor.advisor McDowell, Susan A. en_US
dc.contributor.author Abels, Kristin L. en_US
dc.date.accessioned 2011-06-06T18:23:04Z
dc.date.available 2011-06-06T18:23:04Z
dc.date.created 2007 en_US
dc.date.issued 2007
dc.identifier.other A-330 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/189223
dc.description.abstract Heart disease is the number one killer in the United States. Because this disease is such a prevalent killer, it is necessary to develop a better understanding of the protein pathways involved in the development of pathologic hypertrophy of the heart, which can lead to heart disease. Pathologic hypertrophy is an unhealthy type of enlargement of the tissue and arises from a pressure overload in the heart. Physiologic hypertrophy is a healthy type of hypertrophy and arises from a volume overload in the heart. The difference in the protein pathways involved in these two types of hypertrophy remains largely unknown. Perhaps there is a way to manipulate the proteins in a diseased heart to imitate physiologic hypertrophy in order to block the progression of heart disease. In this research project, a swim-training model was developed to induce cardiac hypertrophy in mice. Heart weight to body weight ratios (HW:BW) were collected for all of the hearts. Homogenates of these hypertrophied hearts as well as those of a control group were used for protein analysis. The difference in the phosphorylation state of Akt (a protein kinase involved in cell survival and cell growth) was determined for the control vs. swim-trained mice. The difference in the phosphorlyation state of p7OS6K (a protein that regulates cell growth and plays a role in the pathway to determination of cell size) also was determined for the control vs. swim-trained mice.
dc.description.sponsorship Honors College
dc.format.extent 34 leaves : ill. ; 30 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Biology. en_US
dc.title The induction of cardiac hypertrophy in mice and the subsequent protein analyses of the heart tissue : an honors thesis (HONRS 499) en_US
dc.type Undergraduate senior honors thesis
dc.description.degree Thesis (B.?.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1370962 en_US


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  • Undergraduate Honors Theses [5928]
    Honors theses submitted to the Honors College by Ball State University undergraduate students in partial fulfillment of degree requirements.

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