Synthesis of 7-N-acetyldemethyllavendamycin cyclohexyl ester : an honors thesis (HONRS 499)

Abstract

The goal of this research project is to synthesize 7- N -acetyldemethyllavendamycin cyclohexyl ester (5). Several analogs have previously been prepared by other researchers at Ball State University under the direction of Dr. Mohammad Behforouz. Lavendamycin analogs are of interest because some have exhibited potent inhibiting capabilities against rasK oncogenic cells.' At the present time there are no available drugs effective against tumors caused by ras K oncogenes.7- N-Acetyldemethyllavendamycin cyclohexyl ester will be synthesized and submitted to our collaborators at Eli Lilly and Company to be tested against oncogene cells. The anticancer activity of this compound will be compared with those of the analogs possessing straight chain ester residues in order to determine the effect of the cyclohexyl group on the anticancer activity.