The effectiveness of free radical initiator 1,1'-azobis (cycohexanecarbonitirile) : an honors thesis (HONRS 499)

Abstract

The project uses 1,1'-azobis(cyclohexanecarbonitrile) to mimic free radical damage done to human erythrocyte cell membranes. Free radical damage to the membrane can be lethal for the cell, but there might also be positive effects for the cell. Zinc is an essential element needed in all the body's cells, unfortunately channels or carries to transport zinc into the cell are only found in certain cells. One proposed mechanism to allow zinc uptake in to the cells is a partially oxidized membrane. This project uses the free radical initiator to controllably oxidize the membrane, and compare its effectiveness to other known free radical initiators.