Synthesis of 3-cyano-2-pyridones from malononitrile : an honors thesis (HONRS 499)

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dc.contributor.advisor Sammelson, Robert E. en_US
dc.contributor.author Huehls, Christopher B. en_US
dc.contributor.author Kite, Camille M.
dc.date.accessioned 2011-06-06T19:00:54Z
dc.date.available 2011-06-06T19:00:54Z
dc.date.created 2009 en_US
dc.date.issued 2009
dc.identifier.other A-338 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/190943
dc.description.abstract Substituted pyridones have multiple known uses in medicinal chemistry including topoisomerase inhibition in anticancer medicines. Cerpegin, a naturally occurring 2-pyridone, functions as an analgesic, anti-ulcer, tranquilizer, and anti-inflammatory. 2-Pyridones have also been associated with antitumor, antifungal, antibacterial, antiviral, and antithrombotic properties. Deri( atives of 2-pyridones are currently being researched as inhibitors of HIV-1 replication. Recently the condensation reaction of malononitrile with aldehydes and ketones has been examined. This condensation is extended to the uncatalyzed reaction of f3-diketones. This reaction requires two equivalents of malononitrile and produces 3-cyano-2-pyridones. An intermediate that provides information about possible mechanistic routes has also been isolated. The reaction pathway explored is ineffective in 13-diektones with large steric hindrances. Single products or multiple isomers in mixed ratios are obtained.
dc.description.sponsorship Honors College
dc.format.extent 20 leaves : ill. ; 28 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Chemistry. en_US
dc.title Synthesis of 3-cyano-2-pyridones from malononitrile : an honors thesis (HONRS 499) en_US
dc.type Undergraduate senior honors thesis.
dc.description.degree Thesis (B.?.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1535217 en_US


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  • Undergraduate Honors Theses [5922]
    Honors theses submitted to the Honors College by Ball State University undergraduate students in partial fulfillment of degree requirements.

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