Predicted binding sites for the regulatory small vault RNAs on messenger RNAs of selected genes relating to cancer, multi-drug resistance, and inflammation : an honors thesis (HONRS 499)

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dc.contributor.advisor Vann, Carolyn N. en_US
dc.contributor.author Jackson, Craig E. en_US
dc.date.accessioned 2011-06-06T19:01:46Z
dc.date.available 2011-06-06T19:01:46Z
dc.date.created 2010 en_US
dc.date.issued 2010
dc.identifier.other A-340 en_US
dc.identifier.uri http://cardinalscholar.bsu.edu/handle/handle/190992
dc.description.abstract Vaults are large ribonucleoprotein particles believed to be involved in multidrug resistance and intracellular transport. The vault complex consists of three proteins and non-coding vault RNAs. It has been shown that the non-coding vault RNA encodes regulatory small vault RNAs (svRNAs). These svRNAs associate with the RNA-induced silencing complex and regulate gene expression similarly to microRNAs. It is unknown which genes the svRNAs regulate, but they are thought to regulate genes relating to multidrug resistance and intracellular antigen transport. I have selected several genes of interest relating to cancer, multidrug resistance, inflammation, and the autoimmune response to predict whether the svRNAs regulate these genes. Since the svRNAs regulate genes similarly to microRNA, I used microRNA target prediction tools to find potential functional binding sites for the svRNAs in the 3' untranslated regions of the selected gene messenger RNAs. I found several target sites that have a very high potential to be functional binding sites for the svRNAs. These results can be used to conduct experiments to verify that the svRNAs bind to the predicted target sites and regulate the expression of the targeted gene.
dc.description.sponsorship Honors College
dc.format.extent 56 leaves : ill. ; 30 cm. en_US
dc.source Virtual Press en_US
dc.subject.lcsh Biology. en_US
dc.title Predicted binding sites for the regulatory small vault RNAs on messenger RNAs of selected genes relating to cancer, multi-drug resistance, and inflammation : an honors thesis (HONRS 499) en_US
dc.type Undergraduate senior honors thesis
dc.description.degree Thesis (B.?.)
dc.identifier.cardcat-url http://liblink.bsu.edu/catkey/1568824 en_US


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  • Undergraduate Honors Theses [5772]
    Honors theses submitted to the Honors College by Ball State University undergraduate students in partial fulfillment of degree requirements.

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