Total synthesis of 7-N-acetyldemethyllavendamycin sec-butyl ester and 7-N-acetyldemethyllavendamycin sec-butyl amide : an honors 499 thesis

Abstract

This thesis is part of ongoing research in the structure-activity relationship studies of various lavendamycin analogs as possible chemotherapeutic agents. The specific work contained in this thesis deals with two very similar analogs of lavendamycin: 7-N-acetydemethyllavendamycin sec-butyl ester and amide. Synthesizing these two similar analogs and eventually testing them for biological activity can obtain a better understanding of the effects of structure on activity. These structure-activity relationship studies are designed to lead to analogs of lavendamycm that have a high selective toxicity for rask oncogene transformed cells.