Total synthesis of 7-N-succinyldemethyllavendamycin esters : an honors thesis [(HONRS 499)]

Abstract

7-N-Succinyldemethyllavendamycin esters-analogs of the naturally occurring, anti-tumor, anti-microbial agent lavendamycin-were synthesized by a six step pathway. These analogs were chosen for their possible biological activity and their solubility in pharmaceutical solvents. NMR spectra, mass spectra, TLC, and melting point studies were performed on the final products and on each intermediate to verify structure and physical properties.