Total synthesis of 7-N-Acetyldemethyllavendamycin Piperazine amide : an honors thesis (HONRS 499)

Abstract

This thesis is part of ongoing research in the structure-activity relationship studies of various lavendamycin analogs as possible chemotherapeutic agents. Lavendamycin and its analogs have proven to be active anti-tumor and anti-cancer compounds in preliminary studies. The specific work contained in this thesis focuses on the synthesis of a new analog of the lavendamycin molecule. This analog was synthesized in hopes of gaining a better understanding of the effects of structure on the activity of the compound and on the solubility of the compound. This in turn will lead to analogs of lavendamycin that have a high selective toxicity and a high level of solubility in physiological solvents.