The current study investigated the ability of scales related to antisocial behavior on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) to relate to and to predict scores on the Machiavellianism Scale (MACH-IV). One hundred and seven participants, 51 men and 56 women, from a Midwestern university (ages 18 to 36, mean =19.5, SD = 2.87) completed the MMPI-2 and the MACH-IV, in addition to other measures, as part of a larger study. Relations between MMPI-2 scales and scores on the MACH-IV were examined using zero-order correlations. Significantly correlated scales were entered into an exploratory stepwise regression analysis in order to determine the most parsimonious set of predictors of MACH-IV scores. Results indicated Machiavellian traits as measured by the MACH-IV could be best accounted for by MMPI-2 Content Scales ASP (Antisocial Practices) and ANG (Anger). These results suggest people with high scores on the MACH-IV may be more likely to engage in anti-social behaviors and have feelings of anger and hostility toward others.