Interaction of pharmaceutical contaminants with amphiphilic monolayers at the lipid-aqueous interface

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Dalla Pozza, Giada
Subir, Mahamud
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Thesis (M.S.)
Department of Chemistry
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Pharmaceutical compounds and personal care products (PPCPs) have been detected in several aquatic environments. These micro-pollutants are introduced in water systems through human and animal excretion as well as through industrial and agricultural processing. They are of concern because some of them bypass the conventional water treatment plants and ultimately are carried in drinking water. Limited information is available about the fate and transport of these organic molecules with respect to their interaction with living matter. Specifically, the interaction between PPCPs and lipid membranes are of particular interest because lipid membranes are common features to living organisms. This study explores the effect of different PPCPs on model lipid membranes made of DPPC at the air-water interface to understand how these contaminants influence the lipid structure. These experiments are carried out with the Langmuir-Blodgett trough technique that allowed us to generate surface pressure vs. molecular area isotherms. The effects of several aqueous concentrations of neutral PPCPs, carbamazepine (CBZ) and estradiol (E2) were compared those of charged species, amlodipine (AMP) and triclosan (TCS). The isotherms obtained with different PPCPs concentrations were then compared to that of DPPC in pure water