The study examined the theoretical and statistical factor structure of the Dean-Woodcock Structured Emotional-Status Exam (D-WESE) and evaluated the prediction of representations of clinical two-point scores representing MMPI codetypes. Analyses provided greater insight into the structure of the measure and its effectiveness in classifying psychopathology. The data of 200 patients referred for a neuropsychological evaluation at a large Midwestern neurology practice was used in this study. Age of patients ranged between 13 and 96 years. An 11-factor exploratory analysis with an oblique rotation and principle axis factoring was compared to the original theoretical model of DSM diagnoses used to develop the 50-items of the measure in order to evaluate the effectiveness of the measure. Regression analyses was incorporated to assess the ability of the relatively brief, 50-item D-WESE to predict representations of 12 codetypes from the 566-item MMPI.