Delirium is one of the most common and detrimental mental health complications of critical care, yet it goes grossly undiagnosed. By gaining a better grasp on the pathophysiologic processes of this condition, we can better understand both how to treat and prevent delirium. Nurses play a pivotal role in detecting the early signs and symptoms because of their constant presence at the bedside. Therefore, it is important to promote educational programs on critical care units to better equip nurses in preventing further complications possible from delirium. Because of the stressful nature of the course of this condition, it is also important to assess the family and caregivers for the emergence of anxiety and caregiver role strain.