Ascorbic acid--oral versus intravenous administrations : effect on urinary excretion profiles and Benzylpenicillin migrates irreversibly into human erythrocytes

A reverse-phase high pressure liquid chromatographic method for the detection and quantitation of unchanged ascorbic acid in human urine is described. Twenty-four hour ascorbate excretion profiles from nine subjects were determined. The urinary excretion profiles for orally ingested and intravenously infused ascorbic acid in these nine subjects are compared.