Total synthesis of 7-N-acetyl-6-ethyl-lavendamycin methyl ester : an honors thesis (HONRS 499)

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Authors
Cunningham, Brian
Advisor
Behforouz, Mohammad
Issue Date
1998
Keyword
Degree
Thesis (B.?)
Department
Honors College
Other Identifiers
Abstract

The research detailed within concerns the synthesis of an analog of lavendamycin; 7-N-acetyl-6-ethyl-lavendamycin methyl ester. This synthesis is part of a continuing structure-activity relationship study of various analogs of lavendamycin as possible chemotherapeutic agents. The eventual screening of this analog for biological activity will further the knowledge of the effects of structure on various biological activities. The molecules selected in this SAR study are chosen in hopes that they will show selective toxicity for rask oncogene transformed cells.