Synthesis of the isoamyl ester of 7-N-acetyl-11'-hydroxy-3'-demethyllavendamycin : an honors thesis (HONRS 499)

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Eads, Thomas J.
Behforouz, Mohammad
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Thesis (B.?.)
Honors College
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The purpose of this project is to synthesize the isoamyl ester of 7-N-acetyl-ill-hydroxy-3'demethyllavendamycin which may potentially be an antitumor drug. Similar compounds have been previously made in our laboratory, but this new compound has two distinctly different groups attached to the N-acetyllavendamycin backbone. These groups will hopefully increase the solubility of the compound in water, thus making it a more practical drug for use in humans, as well as increasing its selectivity in destroying the cancer cells relative to the normal cells. The new compound will be sent to Eli Lilly for testing first in vitro, and then in animals to determine its selectivity and toxicity. Lavendamycinbased drugs offer some hope in treating certain kinds of human cancers for which there are no drugs at the present time.