The total synthesis of 7-N-Butyryl-11'-benzyloxylavendamycin Methyl Ester : an honors thesis (HONRS 499)

Abstract

This thesis is part of an ongoing research project, led by Dr. Behforouz, which studies the structure-activity relationship of various lavendamycin analogs as possible anti-tumor agents. The specific work contained in this thesis is directed toward the synthesis of 7-N-butyryl-11'hydroxylavendamycin methyl ester but ends with the synthesis of 7-N-butyryl-11'-benzyloxylavendamycin methyl ester. By synthesizing these analogs and eventually testing their biological activity, a better understanding of how adding a benzyloxy or a hydroxy functional group affects the activity of the compound. The goal of these structure-activity relationship studies is to develop analogs of lavendamycin that have a high selective toxicity against cancer cells.