The effects of detraining on glucose metabolism in the adipocytes of female rats

Abstract

This study was done to examine the effects of detraining upon the metabolism of glucose by the rats. Thirty-nine female Wister rats were separated into three groups: trained, detrained, and sedentary. The training protocol consisted of swimming 6 hours/day for eight weeks. The detrained groups were then sacrificed at 7, 14, and 21 days after training. The parametrial fat pads were removed and digested into isolated cells. The cell volumes, cell concentrations, and glucose oxidation rates (radioactively labeled C-1 or C-6 glucose) were measured. The results showed that those adaptations in the fat cell brought about by exercise, i.e., 120% decreases adipocyte volume and increased glucose oxidation rates in both pentose phosphate (C-1) cycle and the glycolysis/citric acid cycles, return to the sedentary control levels by 14 days detraining.Ball State UniversityMuncie, IN 47306